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Product info: Diabetes    
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the α-glucosidase inhibitors.

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ROSIGLITAZONE AND METFORMIN (Systemic)


Some commonly used brand names are:

In the U.S.—
Avandamet

In Canada—
Avandamet
Category
Antidiabetic agent
Description

Rosiglitazone and metformin (ROS-e-glit-a-zone and met-FOR-min) combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. Rosiglitazone helps your body use the insulin better and it reduces the amount of insulin in your body. Metformin reduces the absorption of sugar, reduces the release of stored sugar from the liver, and helps your body's cells use sugar better.

This medicine is available only with your doctor's prescription, in the following dosage forms:
Oral
Tablets (U.S.)
Tablets (Canada)
Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rosiglitazone and metformin combination the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to rosiglitazone, metformin or any other ingredients in the medicine. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Rosiglitazone and metformin combination has not been studied in pregnant women or animals. It is easier during pregnancy to control your blood sugar by using injections of insulin rather than by taking oral diabetes medicines. Close control of your blood sugar can reduce the chance of your baby gaining too much weight, having birth defects, or having high blood sugar before birth. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether rosiglitazone or metformin passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of rosiglitazone and metformin in children with use in other age groups.

Older adults—Some older adults may be more sensitive than younger adults to the effects of these medicines. Older adults are more likely to have age-related problems such as kidney problems. Rosiglitazone and metformin should be used carefully as age increases and older adults may need a lower dose of this medicine.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rosiglitazone and metformin, it is especially important that your doctor and pharmacist know if you are taking any of the following:
Alcohol—Drinking alcohol may increase the risk of developing lactic acidosis and/or very low blood sugar.
Beta-adrenergic blocking agents (acebutolol [e.g., Sectral], atenolol [e.g., Tenoretic, Tenormin], betaxolol [e.g., Kerlone], Bisoprolol [e.g., Zebeta, Ziac], carteolol [e.g., Cartrol], carvedilol [e.g., Coreg], labetalol [e.g., Normodyne], metoprolol [e.g., Lopressor, Toprol], nadolol [e.g., Corgard, Corzide], oxprenolol [e.g., Trasicor], penbutolol [e.g., Levatol], pindolol [e.g., Visken], propranolol [e.g., Inderal, Inderide], sotalol [e.g., Betapace, Sorine], timolol [e.g., Blocadren, Timolide])—Beta-adrenergic blocking agents can hide the symptoms of low blood sugar (hypoglycemia). Because of this, a person with diabetes might not recognize that he or she has low blood sugar and might not take immediate steps to treat it.
Amiloride (e.g., Midamor) or
Cimetidine (e.g., Tagamet) or
Digoxin (e.g., Lanoxin) or
Morphine (e.g., MS Contin) or
Procainamide (e.g., Procanbid, Pronestyl) or
Quinidine (e.g., Quinaglute, Quinidex) or
Quinine (malaria medicine) or
Ranitidine (e.g., Zantac) or
Triamterene (e.g., Dyrenium) or
Trimethoprim (e.g., Proloprim) or
Vancomycin (e.g., Vancocin)—Using these medicines with rosiglitazone and metformin may cause there to be too much rosiglitazone and metformin in your body. This may increase the chance of low blood sugar or other side effects.
Furosemide (e.g., Lasix)—Using this medicine with rosiglitazone and metformin may cause there to be too much metformin in your body and a lower dose of rosiglitazone and metformin may be needed.
CYP2C8 inducers (rifampin [e.g., Rifadin])—Your doctor may need to increase your dose of rosiglitazone and metformin.
CYP2C8 inhibitors (gemfibrozil [e.g., Lopid])—Your doctor may need to lower your dose of rosiglitazone and metformin.



 
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